50 HR, 100, RBI, 100 Runs, 100 BB.

21 times by 14 players. Multiple: Ruth 4, McGwire 3, Foxx 2, Mantle 2. Ruth was the only one to lead the league in all four and he did it three times. Most:

HR: Bonds 73 2001
RBI: Wilson 191 1930
Runs: Ruth 177 1921
BB: Bonds 177 2001

Bautista was the only one with OPS below 1.000: .995. Also, lowest BA (.260), OBP (,378), SLG (.617). Highest:

BA: Ruth .378 1921
OBP: Ruth .532 1920
SLG: Bonds .863 2001
OPS: Bonds 1.379 2001, Ruth 1.379 1920

12 of 21 had fewer than 100 SO; Kiner fewest: 61; Howard most: 181.

Rk	Player	HR	R	RBI	BB	Year	Age	Tm	Lg	G	PA	AB	H	2B	3B	IBB	SO	HBP	SH	SF	GDP	SB	CS	BA	OBP	SLG	OPS	Pos
1	Barry Bonds	73	129	137	177	2001	36	SFG	NL	153	664	476	156	32	2	35	93	9	0	2	5	13	3	.328	.515	.863	1.379	*7/DH
2	Mark McGwire	70	130	147	162	1998	34	STL	NL	155	681	509	152	21	0	28	155	6	0	4	8	1	0	.299	.470	.752	1.222	*3/H
3	Mark McGwire	65	118	147	133	1999	35	STL	NL	153	661	521	145	21	1	21	141	2	0	5	12	0	0	.278	.424	.697	1.120	*3/H
4	Sammy Sosa	64	146	160	116	2001	32	CHC	NL	160	711	577	189	34	5	37	153	6	0	12	6	0	2	.328	.437	.737	1.174	*9
5	Babe Ruth	60	158	165	137	1927	32	NYY	AL	151	691	540	192	29	8		89	0	14			7	6	.356	.486	.772	1.258	*97
6	Babe Ruth	59	177	168	145	1921	26	NYY	AL	152	693	540	204	44	16		81	4	4			17	13	.378	.512	.846	1.359	*78/13
7	Ryan Howard	58	104	149	108	2006	26	PHI	NL	159	704	581	182	25	1	37	181	9	0	6	7	0	0	.313	.425	.659	1.084	*3/H
8	Hank Greenberg	58	143	147	119	1938	27	DET	AL	155	681	556	175	23	4		92	3	3			7	5	.315	.438	.683	1.122	*3
9	Jimmie Foxx	58	151	169	116	1932	24	PHA	AL	154	702	585	213	33	9		96	0	0			3	7	.364	.469	.749	1.218	*35
10	Luis Gonzalez	57	128	142	100	2001	33	ARI	NL	162	728	609	198	36	7	24	83	14	0	5	14	1	1	.325	.429	.688	1.117	*7/H
11	Hack Wilson	56	146	191	105	1930	30	CHC	NL	155	709	585	208	35	6		84	1	18			3		.356	.454	.723	1.177	*8
12	Jose Bautista	54	109	124	100	2010	29	TOR	AL	161	683	569	148	35	3	2	116	10	0	4	10	9	2	.260	.378	.617	.995	*95/3D8
13	David Ortiz	54	115	137	119	2006	30	BOS	AL	151	686	558	160	29	2	23	117	4	0	5	12	1	0	.287	.413	.636	1.049	*D3/H
14	Mickey Mantle	54	131	128	126	1961	29	NYY	AL	153	646	514	163	16	6	9	112	0	1	5	2	12	1	.317	.448	.687	1.135	*8/H
15	Ralph Kiner	54	116	127	117	1949	26	PIT	NL	152	667	549	170	19	5		61	1	0		10	6		.310	.432	.658	1.089	*7
16	Babe Ruth	54	163	146	137	1928	33	NYY	AL	154	684	536	173	29	8		87	3	8			4	5	.323	.463	.709	1.172	*97
17	Babe Ruth	54	158	135	150	1920	25	NYY	AL	142	616	458	172	36	9		80	3	5			14	14	.376	.532	.847	1.379	*978/3H1
18	Jim Thome	52	101	118	122	2002	31	CLE	AL	147	613	480	146	19	2	18	139	5	0	6	5	1	2	.304	.445	.677	1.122	*3D/H
19	Mark McGwire	52	104	113	116	1996	32	OAK	AL	130	548	423	132	21	0	16	112	8	0	1	14	0	0	.312	.467	.730	1.198	*3D/H
20	Mickey Mantle	52	132	130	112	1956	24	NYY	AL	150	652	533	188	22	5	6	99	2	1	4	4	10	1	.353	.464	.705	1.169	*8/H
21	Jimmie Foxx	50	139	175	119	1938	30	BOS	AL	149	685	565	197	33	9		76	0	1			5	4	.349	.462	.704	1.166	*3

Provided by Baseball-Reference.com: View Play Index Tool Used
Generated 11/17/2016.