Alex Rodriguez has the record for most four run home runs hit over the fence on the fly. Originally posted 3/11/2013.
Note added 3/2/2014: September 20, 2013 Rodriguez hit what may be his last home run and it came with the bases loaded: number 24 for his career. It broke a 1-1 tie in the 7th inning with the Giants at Yankee Stadium and won the game 5-1. Rodriguez was the designated hitter and batting second.