Most home runs one ballpark: Mel Ott. Sunday, November 8, 2015
Note: This post has been updated 12/16/15 due to two omissions pointed out in a comment below by soxpacker, whom I thank for the information. I apologize for being incorrect in the first place. I also added the parks.
Sosa, Thomas, Ruth and Konerko played in multiple home parks. The others played all their home games in only one ballpark and, except for Gehrig, I don't think the dimensions changed when they played.