Walter and Randy Johnson allowed home runs in first plate appearance (PA) for Luke Stuart and Marcus Thames.

Monday, August 8, 1921

Venue: Griffith Stadium

Game Duration: 1:50

Day Game, on grass

Senators 16, Browns 5

Pitching	IP	H	R	ER	BB	SO	HR	ERA	BF	GSc
Walter Johnson, W (10-10)	9	10	5	4	2	3	1	3.85	41	50
Team Totals	9	10	5	4	2	3	1	4.00	41	50

Marty McManus started at second base for the St. Louis Browns, batting eigth. After going 0 for 3 McManus was replaced by 29 year old rookie Luke Stuart, who had played in a previous game July 28 in New York against the Yankees in the Polo Grounds but not batted. Facing the great Walter Johnson in Washington, D.C. in his first plate appearance (PA), Stuart hit a home run. The next day Stuart got his only start and went 0 for 2. Those three games were his only in the majors. For his three PA Stuart had:

OBP

.333

SLG

1.333

OPS

1.667

OPS+

298

Walter Johnson was 33 years old in 1921. He allowed 7 home runs in 264 innings and led the American League in strike outs with 143. 

At the end of the 1921 season Walter Johnson passed Cy Young for the lead in career strike outs 2,835 to 2,803. Walter Johnson retired after 1927 with 3,509 SO and held the career record until 1982 when Steve Carlton led at the end of the season with 3,709. Carlton was passed in 1984 by Nolan Ryan who has held the record since. Ryan retired after 1993 with 5,714.

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Monday, June 10, 2002

Attendance: 45,698

Venue: Yankee Stadium II

Game Duration: 3:22

Night Game, on grass

Yankees 7, Diamondbacks 5

Pitching	IP	H	R	ER	BB	SO	HR	ERA	BF	Pit	Str	Ctct	StS	StL	GB	FB	LD	Unk	GSc	IR	IS	WPA	aLI	RE24
Randy Johnson, L (9-2)	7.2	7	5	5	3	8	2	2.81	33	134	76	36	18	22	7	14	5	0	50			0.127	1.21	0.7
Bret Prinz, BS (2)	0.1	1	2	2	1	0	1	12.00	3	14	6	4	1	1	0	2	1	0		2	2	-0.617	4.53	-3.4
Team Totals	8	8	7	7	4	8	3	7.88	36	148	82	40	19	23	7	16	6	0	50	2	2	-0.490	1.48	-2.6

HR: Marcus Thames (1, off Randy Johnson, 3rd inn, 1 on, 0 outs to LF-CF)

That gave the Yankees a 2-0 lead. Thames was playing in his first major league game, batting 9th in right field and he homered in his first plate appearance (PA) off the great Randy Johnson.

Randy Johnson was 38 years old and allowed 26 home runs in 2002 but he led the National League in 2002:
Wins 24
Winning "percent" .828
Complete Games 8
Innings 260
Strike Outs 334 (4th consecutive season over 300, 6th and final over all)
ERA+ 195

Randy Johnson retired after 2009 with 4,875 SO, second only to Nolan Ryan. Randy Johnson struck out over 300 batters in six seasons; most 372 in 249.66 innings in 2001, the year before Thames homered off him.

25 year old Thames batted three more times in that game but all were outs. He had 13 PA in 7 games in 2002 but that was his only home run. He played with Texas in 2003 and Detroit 2004-2009, returning to the Yankees for 82 games in 2010. Thames completed his ten year career with 36 games for the Dodgers in 2011. He hit 115 home runs in 1,827 at bats.

August 31, 2006 Randy Johnson was pitching for the Yankees in Yankee Stadium against Detroit and Thames was batting third for the Tigers. In the 9th inning Thames hit his second and final home run off Randy Johnson with a runner on. Johnson was then replaced by Mariano Rivera who got the final three outs in a 6-4 Yankee win. For Thames it was his 24th of 26 home runs in 2006, his most in any season, in only 348 AB. Thames hit 25 in 2008 in 316 AB.

Marcus Thames is currently the batting coach for the New York Yankees.
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http://www.baseball-almanac.com/feats/feats5.shtml

Home Run in First At-Bat (not necessarily first plate appearance)

Fifty-one American League players. Sixty-nine National League players. Two from the American Association...

Twenty-nine of these players didn't even have to wait until the second pitch; they hit their dingers on the first major league pitch they ever saw. Twenty-two did not hit another major league home run. Only four men hit their home runs with the bases loaded -- Bill Duggleby on April 21, 1898; Jeremy Hermida, one-hundred seven years later, on August 31, 2005; Kevin Kouzmanoff on September 2, 2006; and, finally, Daniel Nava on June 12, 2010. Four of these players made their major league debut with one team and had to wait to have their first at-bat when they played for a different team...

50. 118. Tyler Austin (Active) New York 08-13-2016
51. 119. Aaron Judge (Active) New York 08-13-2016
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Austin and Judge are the most recent.