Most career home runs hit AGAINST all 30 teams.

Data derived from https://stathead.com/

Unfortunately, the team name it used does not represent the franchise. Simple example: Brooklyn Dodgers and Los Angeles Dodgers. More confusing: the St. Louis Browns moved to Baltimore and became the Orioles.

Reminder: In the old 154 game schedule through 1960, there were seven opposing teams in each league playing 22 games against each other. That meant many more games against each team. So the career home run leaders against the original teams are dominated by players from long ago. In fact in the AL, Babe Ruth has the record against all seven opponents. But the reverse is also true. The Babe never played against the Colorado Rockies. Ruth has the only two totals over 100.

Babe Ruth

Positions: Outfielder and Pitcher

Bats: Left  •  Throws: Left

6-2, 215lb (188cm, 97kg)

Born: February 6, 1895 in Baltimore, MD us

Died: August 16, 1948 (Aged 53-192d) in New York, NY

Buried: Gate of Heaven Cemetery, Hawthorne, NY

High School: St. Mary's HS (Baltimore, MD)

Debut: July 11, 1914 (Age 19-155d, 4,204th in major league history)
   vs. CLE 7.0 IP, 8 H, 1 SO, 0 BB, 2 ER, W

Last Game: May 30, 1935 (Age 40-113d)
   vs. PHI 1 AB, 0 H, 0 HR, 0 RBI, 0 SB

There is one tie: Mel Ott and Ernie Banks each hit 82 home runs against the Philadelphia Phillies. And there is one player still active in 2021. Find him. Rank (Rk) is in a much longer list of all 98 times players hit at least 60 career home runs against a team.

Below are three lists.

Sorted, sort of, by city:

Rk	Player	Split	From	To	HR	AB	AB/HR	G	GS	PA	R	H	2B	3B	RBI	SB	CS	BB	SO	BA	OBP	SLG	OPS	TB	GDP	HBP	SH	SF	IBB	ROE	BAbip	Player
22	Willie Mays	Atlanta Braves	1951	1973	83	1,335	16.08	377	351	1,538	242	392	58	11	229	32	13	184	169	.294	.378	.540	.918	721	33	6	0	13	21	22	.282	Willie Mays
6	Babe Ruth	Baltimore/St. Louis Browns	1915	1934	96	1,210	12.60	360	346	1,540	311	425	59	21	326	14	16	302	213	.351	.484	.673	1.157	814		10	8		13	15	.365	Babe Ruth
14	Babe Ruth	Boston Red Sox	1920	1934	90	1,030	11.44	293	289	1,290	285	347	61	13	273	23	16	240	139	.337	.464	.683	1.147	704		4	5		25	15	.321	Babe Ruth
9	Willie Mays	Chicago Cubs	1951	1973	92	1,338	14.54	358	347	1,515	268	427	80	17	266	57	18	156	198	.319	.390	.611	1.000	817	26	7	1	13	22	11	.316	Willie Mays
4	Babe Ruth	Chicago White Sox	1915	1934	98	1,188	12.12	354	334	1,491	303	404	74	18	331	16	25	287	174	.340	.470	.680	1.150	808		4	8		25	17	.334	Babe Ruth
5	Henry Aaron	Cincinnati Reds	1954	1974	97	1,403	14.46	372	361	1,579	271	448	81	14	270	33	8	159	155	.319	.388	.604	.993	848	49	5	3	9	27	18	.303	Henry Aaron
10	Babe Ruth	Cleveland Indians	1914	1934	92	1,143	12.42	361	344	1,511	298	405	69	17	278	12	9	349	176	.354	.507	.686	1.193	784		6	6		63	13	.358	Babe Ruth
1	Babe Ruth	Detroit Tigers	1914	1934	123	1,222	9.93	360	346	1,562	338	413	89	19	342	22	25	318	189	.338	.477	.744	1.221	909		8	1		24	12	.319	Babe Ruth
85	Albert Pujols	Houston Astros	2001	2021	62	1,117	18.02	300	293	1,265	175	310	56	2	179	7	1	135	143	.278	.358	.498	.856	556	47	8	0	5	36	16	.270	Albert Pujols
56	Alex Rodriguez	Los Angeles Angels	1995	2016	70	806	11.51	207	206	929	173	257	44	3	169	25	11	90	189	.319	.395	.641	1.036	517	14	19	2	12	6	12	.335	Alex Rodriguez
3	Willie Mays	Los Angeles Dodgers	1951	1973	98	1,414	14.43	383	371	1,641	273	437	75	18	251	33	18	212	209	.309	.400	.595	.995	842	29	7	0	8	30	33	.304	Willie Mays
83	Reggie Jackson	Milwaukee Brewers	1969	1987	62	810	13.06	233	217	938	142	229	35	2	159	23	11	117	204	.283	.378	.560	.939	454	12	9	0	2	10	8	.306	Reggie Jackson
16	Babe Ruth	Washington Senators	1914	1934	89	1,191	13.38	349	337	1,457	276	395	75	34	294	19	16	239	197	.332	.446	.676	1.122	805		6	10		13	11	.338	Babe Ruth
95	Willie Stargell	New York Mets	1963	1982	60	825	13.75	249	213	938	126	237	44	7	182	2	1	94	206	.287	.366	.576	.942	475	14	12	1	6	21	12	.313	Willie Stargell
55	Jimmie Foxx	New York Yankees	1925	1942	70	1,077	15.39	302	284	1,260	195	326	45	20	246	10	11	173	190	.303	.400	.577	.977	621		2	2		12	18	.313	Jimmie Foxx
2	Babe Ruth	Philadelphia Athletics	1915	1934	108	1,181	10.94	347	329	1,487	318	416	66	12	323	15	14	281	195	.352	.479	.703	1.181	830		5	7		28	20	.351	Babe Ruth
23	Ernie Banks	Philadelphia Phillies	1953	1971	82	1,208	14.73	325	315	1,349	199	359	59	12	245	7	5	111	160	.297	.357	.570	.927	688	32	10	6	14	31	27	.283	Ernie Banks
24	Mel Ott	Philadelphia Phillies	1926	1946	82	1,349	16.45	384	360	1,666	304	428	76	10	344	21	12	284	111	.317	.440	.571	1.011	770		12	12		11	23	.299	Mel Ott
21	Mel Ott	Pittsburgh Pirates	1926	1947	83	1,377	16.59	406	377	1,685	285	436	65	7	306	21	11	280	116	.317	.436	.555	.991	764		12	10		22	21	.300	Mel Ott
18	Barry Bonds	San Diego Padres	1986	2007	87	868	9.98	270	263	1,148	222	275	46	4	214	34	11	256	132	.317	.473	.680	1.153	590	10	12	0	12	77	6	.284	Barry Bonds
15	Stan Musial	San Francisco Giants	1942	1963	89	1,494	16.79	417	393	1,764	272	504	82	18	312	8	8	245	101	.337	.432	.595	1.027	889	39	11	6	8	54	18	.316	Stan Musial
13	Henry Aaron	St. Louis Cardinals	1954	1974	91	1,374	15.10	354	351	1,551	248	423	79	8	290	16	11	157	166	.308	.378	.576	.953	791	28	4	4	12	38	22	.294	Henry Aaron
86	David Ortiz	Toronto Blue Jays	1998	2016	62	929	14.98	251	247	1,077	159	258	70	2	192	1	2	140	194	.278	.373	.558	.931	518	20	4	0	4	22	6	.290	David Ortiz
72	Barry Bonds	Washington Nationals	1986	2007	65	800	12.31	227	214	958	180	252	55	5	153	66	11	149	119	.315	.426	.640	1.066	512	12	7	0	2	20	9	.303	Barry Bonds
	Barry Bonds	Colorado Rockies	1993	2007	54	592	10.96																									Barry Bonds
	Reggie Jackson	Texas Rangers	1968	1987	54	802	14.85																									Reggie Jackson
	Rafael Palmeiro	Seattle Mariners	1989	2005	52	793	15.25																									Rafael Palmeiro
	Alex Rodriguez	Kansas City Royals	1995	2015	50	587	11.74																									Alex Rodriguez
	Ryan Howard	Miami Marlins	2004	2016	41	583	14.22																									Ryan Howard
	Alex Rodriguez	Tampa Bay Rays	1998	2016	56	877	15.66																									Alex Rodriguez
	Barry Bonds	Arizona Diamondbacks	1998	2007	39	391	10.03																									Barry Bonds
Rk	Player	Split	From	To	HR	AB	AB/HR	G	GS	PA	R	H	2B	3B	RBI	SB	CS	BB	SO	BA	OBP	SLG	OPS	TB	GDP	HBP	SH	SF	IBB	ROE	BAbip	Player
		min	1914	1934	39	391	9.93
		max	2004	2021	123	1,494	18.02

Sorted by first name to see all the teams against which a player hit the most career home runs. More than one:

Babe Ruth	7	All 7 AL opponents, 2 more than 100
Barry Bonds	4
Willie Mays	3
Alex Rodriguez	3
Mel Ott	2	Both in Pennsylvania
Henry Aaron	2
Reggie Jackson	2

Rk	Player	Split	From	To	HR	AB	AB/HR
85	Albert Pujols	Houston Astros	2001	2021	62	1,117	18.02
56	Alex Rodriguez	Los Angeles Angels	1995	2016	70	806	11.51
	Alex Rodriguez	Kansas City Royals	1995	2015	50	587	11.74
	Alex Rodriguez	Tampa Bay Rays	1998	2016	56	877	15.66
6	Babe Ruth	Baltimore/St. Louis Browns	1915	1934	96	1,210	12.60
14	Babe Ruth	Boston Red Sox	1920	1934	90	1,030	11.44
4	Babe Ruth	Chicago White Sox	1915	1934	98	1,188	12.12
10	Babe Ruth	Cleveland Indians	1914	1934	92	1,143	12.42
1	Babe Ruth	Detroit Tigers	1914	1934	123	1,222	9.93
16	Babe Ruth	Washington Senators	1914	1934	89	1,191	13.38
2	Babe Ruth	Philadelphia Athletics	1915	1934	108	1,181	10.94
18	Barry Bonds	San Diego Padres	1986	2007	87	868	9.98
72	Barry Bonds	Washington Nationals	1986	2007	65	800	12.31
	Barry Bonds	Colorado Rockies	1993	2007	54	592	10.96
	Barry Bonds	Arizona Diamondbacks	1998	2007	39	391	10.03
86	David Ortiz	Toronto Blue Jays	1998	2016	62	929	14.98
23	Ernie Banks	Philadelphia Phillies	1953	1971	82	1,208	14.73
5	Henry Aaron	Cincinnati Reds	1954	1974	97	1,403	14.46
13	Henry Aaron	St. Louis Cardinals	1954	1974	91	1,374	15.10
55	Jimmie Foxx	New York Yankees	1925	1942	70	1,077	15.39
21	Mel Ott	Pittsburgh Pirates	1926	1947	83	1,377	16.59
24	Mel Ott	Philadelphia Phillies	1926	1946	82	1,349	16.45
	Rafael Palmeiro	Seattle Mariners	1989	2005	52	793	15.25
83	Reggie Jackson	Milwaukee Brewers	1969	1987	62	810	13.06
	Reggie Jackson	Texas Rangers	1968	1987	54	802	14.85
	Ryan Howard	Miami Marlins	2004	2016	41	583	14.22
15	Stan Musial	San Francisco Giants	1942	1963	89	1,494	16.79
22	Willie Mays	Atlanta Braves	1951	1973	83	1,335	16.08
9	Willie Mays	Chicago Cubs	1951	1973	92	1,338	14.54
3	Willie Mays	Los Angeles Dodgers	1951	1973	98	1,414	14.43
95	Willie Stargell	New York Mets	1963	1982	60	825	13.75
Rk	Player	Split	From	To	HR	AB	AB/HR
		min	1914	1934	39	391	9.93
		max	2004	2021	123	1,494	18.02

Sorted by home run rate (AB/HR):

Rk	Player	Split	From	To	HR	AB	AB/HR
1	Babe Ruth	Detroit Tigers	1914	1934	123	1,222	9.93
18	Barry Bonds	San Diego Padres	1986	2007	87	868	9.98
	Barry Bonds	Arizona Diamondbacks	1998	2007	39	391	10.03
2	Babe Ruth	Philadelphia Athletics	1915	1934	108	1,181	10.94
	Barry Bonds	Colorado Rockies	1993	2007	54	592	10.96
14	Babe Ruth	Boston Red Sox	1920	1934	90	1,030	11.44
56	Alex Rodriguez	Los Angeles Angels	1995	2016	70	806	11.51
	Alex Rodriguez	Kansas City Royals	1995	2015	50	587	11.74
4	Babe Ruth	Chicago White Sox	1915	1934	98	1,188	12.12
72	Barry Bonds	Washington Nationals	1986	2007	65	800	12.31
10	Babe Ruth	Cleveland Indians	1914	1934	92	1,143	12.42
6	Babe Ruth	Baltimore/St. Louis Browns	1915	1934	96	1,210	12.60
83	Reggie Jackson	Milwaukee Brewers	1969	1987	62	810	13.06
16	Babe Ruth	Washington Senators	1914	1934	89	1,191	13.38
95	Willie Stargell	New York Mets	1963	1982	60	825	13.75
	Ryan Howard	Miami Marlins	2004	2016	41	583	14.22
3	Willie Mays	Los Angeles Dodgers	1951	1973	98	1,414	14.43
5	Henry Aaron	Cincinnati Reds	1954	1974	97	1,403	14.46
9	Willie Mays	Chicago Cubs	1951	1973	92	1,338	14.54
23	Ernie Banks	Philadelphia Phillies	1953	1971	82	1,208	14.73
	Reggie Jackson	Texas Rangers	1968	1987	54	802	14.85
86	David Ortiz	Toronto Blue Jays	1998	2016	62	929	14.98
13	Henry Aaron	St. Louis Cardinals	1954	1974	91	1,374	15.10
	Rafael Palmeiro	Seattle Mariners	1989	2005	52	793	15.25
55	Jimmie Foxx	New York Yankees	1925	1942	70	1,077	15.39
	Alex Rodriguez	Tampa Bay Rays	1998	2016	56	877	15.66
22	Willie Mays	Atlanta Braves	1951	1973	83	1,335	16.08
24	Mel Ott	Philadelphia Phillies	1926	1946	82	1,349	16.45
21	Mel Ott	Pittsburgh Pirates	1926	1947	83	1,377	16.59
15	Stan Musial	San Francisco Giants	1942	1963	89	1,494	16.79
85	Albert Pujols	Houston Astros	2001	2021	62	1,117	18.02
Rk	Player	Split	From	To	HR	AB	AB/HR
		min	1914	1934	39	391	9.93
		max	2004	2021	123	1,494	18.02

Upcoming: the 98 times players hit at least 60 career home runs against a team. For some teams this also shows players with the second most home runs, third most, ...

98 times at least 60 career home runs hit AGAINST a team. Sorted by home runs. Then by team. Monday, November 22, 2021

Link with the data.