50 Home Runs multiple times.

Aaron Judge may hit more in 2022.

						Num	Tot	Ave		team	team	team	team
1	Babe Ruth	54	59	60	54	4	227	56.75	Ruth	Yanks	Yanks	Yanks	Yanks
2	Mark McGwire	52	58	70	65	4	245	61.25	McGwire	As	As/Cards	Cards	Cards
3	Sammy Sosa	66	63	50	64	4	243	60.75	Sosa	Cubs	Cubs	Cubs	Cubs
4	Alex Rodriguez	52	57	54		3	163	54.33	Rodriguez	Rang	Rang	Yanks
5	Jimmie Foxx	58	50			2	108	54.00	Foxx	As	RedSox
6	Ralph Kiner	51	54			2	105	52.50	Kiner	Pir	Pir
7	Mickey Mantle	52	54			2	106	53.00	Mantle	Yanks	Yanks
8	Willie Mays	51	52			2	103	51.50	Mays	Giants	Giants
9	Ken Griffey	56	56			2	112	56.00	Griffey	Mar	Mar
10	Aaron Judge	52	55			2	107	53.50	Judge	Yanks	Yanks