Ruth, Gehrig, DiMaggio, Mantle: no Home Runs against the same pitcher.

There was no one pitcher who gave up home runs to the Yankees big four.

Yankees with at least 350 home runs:

Rk ▲	Player	HR	AB	From	To	Age	G	PA	R	H	2B	3B	RBI	BB	IBB	SO	HBP	SH	SF	GDP	SB	CS	BA	OBP	SLG	OPS	Pos
1	Babe Ruth	659	7217	1920	1934	25-39	2084	9199	1959	2518	424	106	1978	1852		1122	35	94			110	117	.349	.484	.711	1.195	*97/8H31
2	Mickey Mantle	536	8102	1951	1968	19-36	2401	9907	1676	2415	344	72	1509	1733	148	1710	13	14	47	113	153	38	.298	.421	.557	.977	*8397H/645
3	Lou Gehrig	493	8001	1923	1939	20-36	2164	9665	1888	2721	534	163	1995	1508		790	45	106		2	102	100	.340	.447	.632	1.080	*3/H976
4	Joe DiMaggio	361	6821	1936	1951	21-36	1736	7672	1390	2214	389	131	1537	790	74	369	46	14		130	30	9	.325	.398	.579	.977	*8/79H3
5	Yogi Berra	358	7546	1946	1963	21-38	2116	8350	1174	2148	321	49	1430	704	91	411	52	9	44	146	30	26	.285	.348	.483	.830	*2H79/35
6	Alex Rodriguez	351	5577	2004	2016	28-40	1509	6520	1012	1580	263	9	1096	779	60	1292	104	0	60	151	152	30	.283	.378	.523	.900	*5D/H63

Ruth started and ended with Boston: first as a lefty pitcher for the Red Sox and finally the start of the 1935 season with the Braves (first NL home run opening day off Carl Hubbell). The Braves left Boston for Milwaukee and then Atlanta. Gehrig, DiMaggio and Mantle played their entire careers for the Yankees.

Note the Yankee overlap:
Ruth 1920-1934
Gehrig 1923-1939
DiMaggio 1936-1951
Mantle 1951-1968

A somewhat crude method was used to check: comparing the lists of pitchers who gave up home runs to Ruth and Mantle at the end of Ruth's career, including the seven Ruth hit for the Braves in 1935, and the beginning of Mantle's career. Google Docs Sheet helped facilitate by eliminating duplicates from each list for pitchers who gave up multiple home runs to either. Sorted by first/last name:

Mantle 1951-1952	Ruth 1933-1935
Alex Kellner	Bill Dietrich
Art Houtteman	Bob Kline
Bill Wight	Bob Weiland
Billy Hoeft	Bobby Coombs
Bob Cain	Carl Hubbell
Bob Hooper	Chad Kimsey
Bob Lemon	Dick Coffman
Bob Porterfield	Elden Auker
Bobby Shantz	Fritz Ostermueller
Chuck Stobbs	General Crowder
Dick Rozek	George Blaeholder
Dick Starr	Guy Bush
Duane Pillette	Ivy Andrews
Early Wynn	Jack Knott
Ellis Kinder	Jim Weaver
Hal Newhouser	Johnny Welch
Harry Byrd	Lefty Grove
Joe Dobson	Lefty Stewart
Lou Brissie	Mel Harder
Lou Kretlow	Milt Gaston
Marlin Stuart	Monte Pearson
Marv Grissom	Monte Weaver
Mel Parnell	Oral Hildebrand
Mike Garcia	Ray Benge
Ralph Brickner	Red Faber
Randy Gumpert	Red Lucas
Satchel Paige	Sad Sam Jones
Sid Hudson	Schoolboy Rowe
Steve Gromek	Sugar Cain
Ted Gray	Syd Cohen
Virgil Trucks	Ted Lyons
	Tex Carleton
	Tim McKeithan
	Tommy Bridges
	Tommy Thomas
	Tony Freitas
	Vic Frazier
	Whit Wyatt

No pitcher appears on both lists.

In DiMaggio's 1936 rookie season Gehrig hit the most home runs against any one team in a season by any hitter ever: 14 against Cleveland:

1936	#car	#yr	#gm	Date	@Bat	At	Team	Pitcher	Score	Inn	Out	RoB	RBI	BOP	Pos	WPA	bWE	Notes
392	392	14	2	1936-06-16	NYY	@	CLE	Denny Galehouse	behind 3-8	t 7	2	---	1	4	3	.022	5%
384	384	6	1	1936-05-19	NYY	@	CLE	George Blaeholder	tied 2-2	t 6	0	---	1	4	3	.135	63%
391	391	13	1	1936-06-16	NYY	@	CLE	George Blaeholder	behind 0-4	t 2	0	---	1	4	3	.063	25%
394	394	16	1	1936-06-18	NYY	@	CLE	Johnny Allen	behind 1-2	t 6	2	---	1	4	3	.138	43%
399	399	21	1	1936-07-09	NYY		CLE	Johnny Allen	ahead 1-0	b 1	1	-2-	2	4	3	.120	77%
423	423	45	1	1936-09-10	NYY	@	CLE	Johnny Allen	ahead 2-0	t 3	2	---	1	4	3	.084	73%
381	381	3	1	1936-04-28	NYY		CLE	Lloyd Brown	tied 0-0	b 5	0	---	1	4	3	.124	70%
387	387	9	1	1936-06-05	NYY		CLE	Lloyd Brown	behind 0-1	b 6	2	---	1	4	3	.167	52%	IPHR
400	400	22	1	1936-07-10	NYY		CLE	Lloyd Brown	tied 0-0	b 1	2	--3	2	4	3	.150	69%
401	401	23	2	1936-07-10	NYY		CLE	Lloyd Brown	ahead 3-0	b 3	0	1--	2	4	3	.078	92%
388	388	10	1	1936-06-06	NYY		CLE	Mel Harder	behind 0-1	b 2	0	---	1	4	3	.096	56%
411	411	33	1	1936-07-31	NYY	@	CLE	Mel Harder	ahead 4-2	t 5	1	1--	2	4	3	.135	85%
422	422	44	1	1936-09-09	NYY	@	CLE	Oral Hildebrand	ahead 3-0	t 2	1	123	4	4	3	.120	92%
393	393	15	1	1936-06-17	NYY	@	CLE	Thornton Lee	ahead 8-1	t 6	2	---	1	4	3	.012	98%

This is mostly just a point of interest. Roger Maris hit 13 against the White Sox in 1961.

August 15, 1936 in Shibe Park Philadelphia 18 year old rookie pitcher Randy Gumpert gave up the second home run of his career:

HR: Lou Gehrig (36, off Randy Gumpert, 8th inn, 3 on, 1 out to RF); Crosetti Scores; Rolfe Scores; DiMaggio Scores

Obviously Gumpert never even pitched to Ruth but he did give up homers to DiMaggio and number one to Mantle May 1, 1951 in Comiskey Park Chicago:

Mickey Mantle (1, off Randy Gumpert, 6th inn, 1 on, 1 out to RF).

Gumpert's last home run allowed: August 30, 1952 Yankee Stadium:

HR: Mickey Mantle (19, off Randy Gumpert, 3rd inn, 0 on, 0 outs to RF)

June 8, 1936 in Yankee Stadium Gehrig and DiMaggio homered in the same game for the first time and it happened to be against the same pitcher:

HR: Joe DiMaggio (5, off Jack Knott, 5th inn, 1 on, 0 outs to LF); Lou Gehrig (11, off Jack Knott, 5th inn, 0 on, 0 outs to CF).
Jack Knott was a righty who pitched in the American League full time 1933-1942.  His most home runs allowed:

Jimmie Foxx	11
Joe DiMaggio	9
Pinky Higgins	7
Earl Averill	6
Lou Gehrig	6

But only one to Ruth: May 28, 1934 in Sportsman's Park III in St. Louis pitching for the Browns: top 7, Babe Ruth (8); Lou Gehrig 2 (12).

There was a lefty Dutch Leonard (1913-1921, 1924, 1925); Ruth hit five homers off him. Gehrig did not homer against him.

Righty Dutch Leonard pitched 1933-1953 (not 1937) and gave up 158 home runs. Leonard only pitched for Washington in the AL 1938-1946 so he could not have given up home runs to Mantle and to Ruth only in 1935 when Ruth played for the Braves when Leonard was pitching for his original team, the Brooklyn Dodgers: 138 innings, 11 homers but none to Ruth. Leonard did allow three homers to DiMaggio and one to Gehrig while pitching for Washington. It was the final home run of Gehrig's career.

September 27, 1938 in Yankee Stadium:

HR: Lou Gehrig (29, off Dutch Leonard, 5th inn, 0 on, 1 out).

Gehrig did not homer in 14 AB in the 1938 World Series sweep of the Chicago Cubs. In 1939 at age 36 Gehrig appeared in just 8 games, 33 PA, four singles in 28 AB.

In their one season as teammates DiMaggio (36) and Mantle (19) did not homer in the same game. They both homered against two pitchers in 1951:
- Lew Kretlow. Both hit two homers off Kretlow, DiMaggio hit both in the same game.
- Dick Starr

DiMaggio:

																	70%		Home Run; Berra Scores/unER; DiMaggio Scores/unER
1951	#car	#yr	#gm	Date	@Bat			Pitcher	Score	Inn	Out	RoB	RBI	BOP	Pos	WPA	bWE	Notes	Play Description
350	350	1	1	1951-04-27	NYY	@	BOS	Mel Parnell	behind 1-4	t 6	0	---	1	4	8	0.084	23%		Home Run
351	351	2	1	1951-04-28	NYY		WSH	Al Sima	behind 0-2	b 1	2	1--	2	4	8	0.190	51%		Home Run; Coleman Scores
352	352	3	1	1951-05-20	NYY		SLB	Dick Starr	ahead 4-1	b 5	1	1--	2	4	8	0.071	96%		Home Run; Mantle Scores
353	353	4	1	1951-05-24	NYY		DET	Bob Cain	ahead 3-1	b 6	1	-2-	2	4	8	0.088	95%		Home Run; Mantle Scores/unER
354	354	5	1	1951-05-30 (2)	NYY	@	BOS	Willard Nixon	behind 1-2	t 6	0	12-	3	4	8	0.272	77%		Home Run; Rizzuto Scores; Brown Scores
355	355	6	1	1951-06-07	NYY	@	SLB	Al Widmar	behind 3-5	t 8	1	---	1	4	8	0.101	20%		Home Run
356	356	7	1	1951-07-27	NYY		CHW	Billy Pierce	ahead 2-1	b 8	2	---	1	4	8	0.084	93%		Home Run
357	357	8	1	1951-07-29 (1)	NYY		CHW	Lou Kretlow	behind 0-2	b 1	2	-2-	2	4	8	0.181	51%		Home Run; Collins Scores
358	358	9	2	1951-07-29 (1)	NYY		CHW	Lou Kretlow	ahead 5-2	b 6	2	12-	3	4	8	0.073	99%		Home Run; Collins Scores; Brown Scores
359	359	10	1	1951-08-09	NYY		WSH	Julio Moreno	behind 2-4	b 6	0	---	1	4	8	0.138	39%		Home Run
360	360	11	1	1951-08-26 (1)	NYY	@	CHW	Saul Rogovin	tied 0-0	t 2	0	---	1	4	8	0.104	60%		Home Run
361	361	12	1	1951-09-28 (2)	NYY		BOS	Chuck Stobbs	ahead 7-3	b 6	2	-23	3	4	8	0.038	99%		Home Run; Coleman Scores; Bauer Scores

Mantle:

Year	#car	#yr	#gm	theDate	dhG	@Bat	At	Opp	Pitcher	Score	Inn	Out	RoB	RBI	BOP	Pos	WPA	bWE	Notes
1	1	1	1	Tue, May 1, 1951		NYY	@	CHW	Randy Gumpert	ahead 5-3	t 6	1	-2-	2	1	9	.117	91%
2	2	2	1	Fri, May 4, 1951		NYY	@	SLB	Duane Pillette	ahead 2-1	t 6	2	1--	2	1	9	.213	84%
3	3	3	1	Sun, May 13, 1951	1	NYY	@	PHA	Alex Kellner	behind 1-4	t 6	0	1--	2	2	9	.162	34%
4	4	4	1	Wed, May 16, 1951		NYY		CLE	Dick Rozek	ahead 9-2	b 8	2	1--	2	2	9	.001	100%
5	5	5	1	Tue, Jun 19, 1951	1	NYY		CHW	Lou Kretlow	tied 6-6	b 3	1	12-	3	1	9	.236	83%
6	6	6	1	Tue, Jun 19, 1951	2	NYY		CHW	Joe Dobson	tied 1-1	b 6	1	---	1	1	9	.181	72%
7	7	7	1	Sat, Jul 7, 1951		NYY	@	BOS	Ellis Kinder	behind 3-10	t 9	0	---	1	3	9	.002	0%
8	8	8	1	Sat, Aug 25, 1951		NYY	@	CLE	Mike Garcia	tied 1-1	t 3	1	1--	2	2	9	.199	70%
9	9	9	1	Wed, Aug 29, 1951		NYY	@	SLB	Satchel Paige	ahead 12-2	t 9	2	12-	3	1	9	.000	100%
10	10	10	1	Sat, Sep 8, 1951		NYY		WSH	Bob Porterfield	tied 0-0	b 7	2	12-	3	1	9	.360	93%
11	11	11	1	Sun, Sep 9, 1951	1	NYY		WSH	Dick Starr	ahead 4-3	b 7	1	---	1	1	9	.107	88%
12	12	12	1	Thu, Sep 13, 1951		NYY		DET	Virgil Trucks	tied 0-0	b 1	0	---	1	1	9	.100	65%	Lead-Off
13	13	13	1	Wed, Sep 19, 1951		NYY		CHW	Lou Kretlow	tied 2-2	b 4	2	12-	3	1	9	.295	85%

Yes, DiMaggio's final home run was against lefty Chuck Stobbs 1947-1961. Mantle immortalized Stobbs in 1953 by hitting the first "tape measure" home run, i.e., a home run whose distance was supposedly measured by a Yankee publicity person as traveling 565 feet on a fly and out of Griffith Stadium in Washington, DC.

Most career home runs through 1938:

Rk	Player	HR	From	To	Age	G	PA	AB	R	H	2B	3B	RBI	BB	IBB	SO	HBP	SH	SF	GDP	SB	CS	BA	OBP	SLG	OPS	Pos	Tm
1	Babe Ruth	714	1914	1935	19-40	2503	10623	8399	2174	2873	506	136	2214	2062		1330	43	113		2	123	117	.342	.474	.690	1.164	971/H83	BOS-NYY-BSN
2	Lou Gehrig	493	1923	1938	20-35	2156	9632	7973	1886	2717	534	163	1994	1503		789	45	106			102	100	.341	.448	.634	1.082	*3/H976	NYY
3	Jimmie Foxx	429	1925	1938	17-30	1710	7293	6116	1355	2049	346	102	1520	1104		935	9	61			76	58	.335	.437	.635	1.073	*35/H2796	PHA-BOS
4	Mel Ott	342	1926	1938	17-29	1739	7300	6148	1247	1939	336	61	1306	1035		516	37	74		44	60		.315	.417	.557	.974	*958H/74	NYG
5	Rogers Hornsby	301	1915	1937	19-41	2259	9480	8173	1579	2930	541	169	1584	1038		679	48	216		3	135	64	.358	.434	.577	1.010	*465H/3978	STL-NYG-BSN-CHC-SLB

Most career home runs through 1951:

Rk	Player	HR	From	To	Age	G	PA	AB	R	H	2B	3B	RBI	BB	IBB	SO	HBP	SH	SF	GDP	SB	CS	BA	OBP	SLG	OPS	Pos	Tm
1	Babe Ruth	714	1914	1935	19-40	2503	10623	8399	2174	2873	506	136	2214	2062		1330	43	113		2	123	117	.342	.474	.690	1.164	971/H83	BOS-NYY-BSN
2	Jimmie Foxx	534	1925	1945	17-37	2317	9676	8134	1751	2646	458	125	1922	1452	16	1311	13	71		69	87	76	.325	.428	.609	1.038	*3H52/7916	PHA-BOS-CHC-PHI
3	Mel Ott	511	1926	1947	17-38	2730	11348	9456	1859	2876	488	72	1860	1708	39	896	64	109		82	89	16	.304	.414	.533	.947	*95H8/74	NYG
4	Lou Gehrig	493	1923	1939	20-36	2164	9665	8001	1888	2721	534	163	1995	1508		790	45	106		2	102	100	.340	.447	.632	1.080	*3/H976	NYY
5	Joe DiMaggio	361	1936	1951	21-36	1736	7672	6821	1390	2214	389	131	1537	790	74	369	46	14		130	30	9	.325	.398	.579	.977	*8/79H3	NYY
6	Johnny Mize	351	1936	1951	23-38	1725	7102	6202	1103	1949	355	83	1281	833	69	492	48	20		92	28	6	.314	.400	.568	.968	*3/H9	STL-NYG-NYY

Most career home runs through 1968:

Rk	Player	HR	From	To	Age	G	PA	AB	R	H	2B	3B	RBI	BB	IBB	SO	HBP	SH	SF	GDP	SB	CS	BA	OBP	SLG	OPS	Pos	Tm
1	Babe Ruth	714	1914	1935	19-40	2503	10623	8399	2174	2873	506	136	2214	2062		1330	43	113		2	123	117	.342	.474	.690	1.164	971/H83	BOS-NYY-BSN
2	Willie Mays	587	1951	1968	20-37	2446	10386	9130	1763	2812	446	129	1654	1137	187	1147	33	7	76	212	299	93	.308	.384	.578	.962	*8/H96375	NYG-SFG
3	Mickey Mantle	536	1951	1968	19-36	2401	9907	8102	1676	2415	344	72	1509	1733	148	1710	13	14	47	113	153	38	.298	.421	.557	.977	*8397H/645	NYY
4	Jimmie Foxx	534	1925	1945	17-37	2317	9676	8134	1751	2646	458	125	1922	1452	16	1311	13	71		69	87	76	.325	.428	.609	1.038	*3H52/7916	PHA-BOS-CHC-PHI
5	Ted Williams	521	1939	1960	20-41	2292	9788	7706	1798	2654	525	71	1839	2021	243	709	39	5	20	197	24	17	.344	.482	.634	1.116	*79H/1	BOS
6	Eddie Mathews	512	1952	1968	20-36	2391	10100	8537	1509	2315	354	72	1453	1444	142	1487	26	36	58	123	68	39	.271	.376	.509	.885	*53/H7	BSN-MLN-ATL-HOU-DET
7	Mel Ott	511	1926	1947	17-38	2730	11348	9456	1859	2876	488	72	1860	1708	39	896	64	109		82	89	16	.304	.414	.533	.947	*95H8/74	NYG
8	Hank Aaron	510	1954	1968	20-34	2279	9888	8889	1603	2792	484	88	1627	866	200	991	23	19	91	239	215	59	.314	.373	.560	.933	*987/4H35	MLN-ATL
9	Lou Gehrig	493	1923	1939	20-36	2164	9665	8001	1888	2721	534	163	1995	1508		790	45	106		2	102	100	.340	.447	.632	1.080	*3/H976	NYY
10	Stan Musial	475	1941	1963	20-42	3026	12718	10972	1949	3630	725	177	1951	1599	298	696	53	35	53	243	78	71	.331	.417	.559	.976	3798H/1	STL
11	Ernie Banks	474	1953	1968	22-37	2262	9427	8551	1216	2368	380	86	1480	695	191	1088	62	33	86	208	50	53	.277	.333	.508	.840	63/5H7	CHC
12	Frank Robinson	418	1956	1968	20-32	1916	8159	7003	1317	2117	402	60	1277	929	158	1047	147	13	68	185	182	67	.302	.392	.556	.948	9738/H5	CIN-BAL
13	Duke Snider	407	1947	1964	20-37	2143	8237	7161	1259	2116	358	85	1333	971	154	1237	21	52	32	166	99	73	.295	.380	.540	.919	*89H/7	BRO-LAD-NYM-SFG

Ruth, Gehrig, DiMaggio, Mantle: Home Runs by the same pitcher to 3 of 4. Wednesday, May 29, 2019